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N-terminal Pro-Brain Natriuretic Peptide Testing in the Emergency Department: Beneficial Effects on Hospitalization, Costs, and Outcome
Introduction of NT-pro-BNP testing for HF in the ED setting reduces the time to discharge and is associated with a trend toward cost reduction. But does cost savings adversely impact 30-day outcomes?
Journal Article, October 10, 2008
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Mechanisms of Disease: The Evolving Role of Regulatory T Cells in Atherosclerosis
The role of regulatory T cells in atherosclerosis development is examined in this review article. Future therapies designed to attenuate atheroscelerosis through this mechanism may be forthcoming.
Journal Article, October 10, 2008
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Radioimmunological Detection of Anti-transglutaminase Autoantibodies in Human Saliva: A Useful Test To Monitor Coeliac Disease Follow-up
Serum radioimmunoassay (RIA) tissue transglutaminase autoantibodies (tTG-Abs) proved to be a sensitive test also during coeliac disease follow-up. The authors demonstrate that RIA tTG-Abs could be detected in human saliva.
Journal Article, October 10, 2008
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Why and How to Use the Photographic Atlases of the American Registry of Pathology
William A. Gardner, MD, Executive Director, American Registry of Pathology, Silver Spring, Maryland, describes the importance of visual images to medicine.
Editorial, October 10, 2008
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Lymphocytic Esophagitis: A Chronic or Recurring Pattern of Esophagitis Resembling Allergic Contact Dermatitis
Medical records of 42 lymphocytic esophagitis cases were reviewed. Were patients with lymphocytic esophagitis more likely than control subjects to have Crohn's disease?
Journal Article, October 9, 2008
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Miscarriage and Its Associations
Miscarriage is most commonly caused by abnormal chromosome number, but nonchromosomal factors can also be causes. What is the scope of miscarriage and the clinical circumstances in which it arises?
Journal Article, October 8, 2008
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Procalcitonin in Liver Transplantation: Are High Levels due to Donors or Recipients?
Do procalcitonin (PCT) levels predict complications in post orthotopic liver transplant recipients? Learn more about the source of PCT increase after transplantation.
Journal Article, October 8, 2008
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Elevated Autoantibody Content in Rheumatoid Arthritis Synovia With Lymphoid Aggregates and the Effect of Rituximab
This article includes a review of the ARISE (Assessment of Rituximab's Immunomodulatory Synovial Effects) trial.
Journal Article, October 8, 2008
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Analysis of Oxidative DNA Damage in Patients with Colorectal Cancer
Can measurement of oxidative damage at various stages of colorectal cancer help determine the effectiveness of antioxidant agents and prevent initial oxidative stress in the colon?
Journal Article, October 8, 2008
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Laboratory Surveillance for Wild and Vaccine-Derived Polioviruses -- Worldwide, January 2007-June 2008
What have been the Global Polio Laboratory Network activities and wild and vaccine-derived poliovirus surveillance during January 2007 to June 2008?
Journal Article, October 8, 2008
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Role of Human Papillomavirus Types 16, 18, and 52 in Recurrent Cystitis and Urinary Bladder Cancer Among Egyptian Patients
We estimated the prevalence of HPV-16, -18, and -52 in bladder cancer or recurrent cystitis and studied the correlation of type-specific HPV-IgG with PCR results and clinicopathologic parameters.
Journal Article, October 8, 2008
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CME/CE
A 14-Year-Old Boy With Progressive Weakness and Dyspnea
A 14-year-old boy presents to the ED with a 10-day history of progressive weakness following symptoms of an upper respiratory infection. The patient’s weakness is affecting his extremities, and he has developed shortness of breath and difficulty urinating. The patient is sent for magnetic resonance imaging (MRI) of his brain and spine. What is the patient’s condition as verified by the MRI?
Clinical Case, October 8, 2008
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The Impact of Genomics in Understanding Human Melanoma Progression and Metastasis
High-throughput gene expression analysis: What is its role in understanding the specific genes and pathways involved in primary and metastatic melanoma?
Journal Article, October 7, 2008
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Variants in Iron Metabolism Genes Predict Higher Blood Lead Levels in Young Children
Iron metabolism genes could modify lead absorption and stores. How might genetic variants of iron metabolism (hemochromatosis and transferrin genes) affect blood lead levels in young children?
Journal Article, October 7, 2008
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Modification of Solid Phase Red Cell Adherence Assay for the Detection of Platelet Antibodies in Patients With Thrombocytopenia
Current methods used to detect antiplatelet antibodies have limitations. This modified technique had a sensitivity of 98% and a specificity of 91%.
Journal Article, October 6, 2008
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Scientists Discover Neuroblastoma Gene
The author discusses new findings about a genetic cause of neuroblastoma.
Expert Viewpoint, October 6, 2008
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Let's Not Give Up on Dual Antibodies in Colon Cancer...Yet
In this video blog, Dr. John Marshall observes that despite unexpected negative results in the PACCE and CAIRO2 trials, dual antibody therapy may yet play a role in colorectal cancer.
Expert Viewpoint, October 4, 2008
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Findings on Optical Colonoscopy After Positive CT Colonography Exam
The aim of this study is to evaluate the findings on optical colonoscopy (OC) after a positive CT colonography (CTC) exam and characterize the type of polyps seen on OC but not reported by CTC.
Journal Article, October 3, 2008
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Doing Better for Less: The Case for Organized Group Practices
Shannon Brownlee, MS, Visiting Scholar, National Institutes of Health, Washington, DC, explains how to both cut healthcare costs and improve quality.
Editorial, October 3, 2008
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A Comparison of Two Methods to Determine the Presence of High-risk HPV Cervical Infections
The clinical viability of a laboratory-developed test using the Invader HPV reagents was determined.
Journal Article, October 2, 2008
